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May 1, 20261 citations

Machine-Learning-Guided Discovery of Cytochrome P450 Enzymes for Bioproduction of Jolkinolides and Other Labdane-Related Diterpenoids.

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KLKaizhou LuRZRui ZhangKGKe Gao

Key Points

  • The aim is to discover cytochrome P450 enzymes from plant genomes for bioproduction of valuable diterpenoids.
  • Utilized machine learning algorithms to identify CYPs from genomic data.
  • Evaluated enzymatic activity for the production of jolkinolides and labdane-related diterpenoids.
  • Identified several high-performance cytochrome P450 enzymes that enhance the bioproduction process.
  • Provided an enriched set of enzymatic catalysts for upcoming bioproduction applications.

Abstract

, respectively. These findings provide a high-performance approach for identifying CYPs from plant genomes and enrich the enzymatic catalysts for bioproduction of jolkinolides and other valuable LRDs.

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Cite This Study

Lu et al. (2026) studied this question.

synapsesocial.com/papers/69f443e8967e944ac5566f7fhttps://doi.org/10.1021/jacs.6c05010
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