Associations of circulating resistin with Alzheimer's disease biomarkers and cognitive function in the preclinical stage of Alzheimer's disease

; however, after correcting for multiple comparisons, there were no significant associations with any AD biomarkers. Furthermore, plasma resistin concentrations were significantly associated with semantic fluency but not with episodic memory or executive function. In women, plasma resistin concentrations were similar between preclinical AD and controls, and there were no significant associations with CSF AD biomarkers and cognitive measures.ConclusionsThese findings raise the possibility that, in men, alterations in peripheral resistin signaling occur during the earliest stages of AD and could represent an early link between systemic metabolic and inflammation dysregulation in AD.