Hydrogen Isotope Exchange in Pyridine Catalyzed by an Iron(II) Imido Complex: Counterion-Directed Regioselectivity.

Bin Feng; G Li; Yafei Gao; Nobuyuki Yamamoto; Maren Pink; Qian Peng; Jeremy M. Smith

doi:10.1002/anie.4646822

April 28, 2026

Hydrogen Isotope Exchange in Pyridine Catalyzed by an Iron(II) Imido Complex: Counterion-Directed Regioselectivity.

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Key Points

To investigate how an iron(II) imido complex facilitates regioselective deuteration of pyridine using a counter-cation.
Utilized iron(II) imido complex as a catalyst for deuteration.
Examined the impact of counter-cations on regioselectivity during deuteration of pyridine.
Achieved regioselective α,β,γ- and β,γ-deuteration of pyridine.
Identified that counter-cation stabilizes specific pyridyl regioisomers for selective deuteration.

Implication

Experimental work reveals counter-cation role in regioselective deuteration of pyridine, indicating new pathways for chemical synthesis.

Abstract

catalyzes regioselective α,β,γ- and β,γ-deuteration of pyridine. Here, the counter-cation stabilizes the appropriate pyridyl regioisomer for the selectivity-determining deuteration step.

Discussion

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Cite This Study

Feng et al. (2026) studied this question.

synapsesocial.com/papers/69f44420967e944ac5567265 https://doi.org/10.1002/anie.4646822

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Hydrogen Isotope Exchange in Pyridine Catalyzed by an Iron(II) Imido Complex: Counterion-Directed Regioselectivity.

Key Points

Implication

Abstract

Discussion

Cite This Study

Hydrogen Isotope Exchange in Pyridine Catalyzed by an Iron(II) Imido Complex: Counterion-Directed Regioselectivity.

Key Points

Implication

Abstract

Discussion

Cite This Study

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