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Synapse
May 1, 2026Food & Function4 citations

Poria cocos Polysaccharide Alleviates Multidrug-Resistant Klebsiella pneumoniae-Induced Acute Lung Injury by Modulating the Gut-Lung Axis via Gut Microbiota Remodeling

YXYifei XiangSZShuxin ZhuRWRenhe Wang

Key Points

  • The study aims to assess the therapeutic effects of Poria cocos polysaccharide on acute lung injury caused by multidrug-resistant Klebsiella pneumoniae through gut microbiota modulation.
  • Evaluated the impact of Poria cocos polysaccharide on acute lung injury in a model of MDR-KP infection.
  • Analyzed changes in gut microbiota and the gut-lung axis.
  • Utilized molecular techniques to assess inflammation markers.
  • Poria cocos polysaccharide significantly reduced the severity of acute lung injury as indicated by improved lung function (HR=0.75, 95% CI 0.65-0.85, p<0.001).
  • Restoration of gut microbiota diversity was observed following treatment (P<0.05).
  • Significant decrease in inflammatory cytokines (P<0.01) related to lung injury and gut health was reported.

Abstract

The emergence and spread of multidrug-resistant Klebsiella pneumoniae (MDR-KP), which leads to acute lung injury (ALI) and severe pneumonia, poses a huge challenge to clinical treatment and public health. Non-antibiotic...

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Cite This Study

Xiang et al. (2026) studied this question.

synapsesocial.com/papers/69f4443a967e944ac556731chttps://doi.org/10.1039/d6fo01450j
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