Key result
Increased carotid intima-media thickness (CIMT >0.8mm) did not demonstrate a statistically significant association with angiographic vessel involvement in patients with acute cardiac ischemia (OR 1.50, P=0.400).
Why the study?
The study was conducted to evaluate the relationship between carotid intima-media thickening and subclinical myocardial ischemia in patients with acute cardiac ischemia.
Does increased Carotid Intima-Media Thickness (CIMT > 0.8 mm) predict the severity of coronary vessel involvement in patients presenting with acute cardiac ischemia?
Observational (n=75)
Yes
Does increased Carotid Intima-Media Thickness (CIMT > 0.8 mm) predict the severity of coronary vessel involvement in patients presenting with acute cardiac ischemia?
In patients with acute cardiac ischemia, increased Carotid Intima-Media Thickness (CIMT) was commonly observed but did not statistically significantly predict the severity of coronary vessel involvement on angiography.
Answers are grounded in this paper and cite their sources.
No significant CIMT association should not yet change risk assessment; leaves open its predictive value in acute ischemia.
Background: The present study aimed to evaluate the relationship between Carotid intima-media thickening (CIMT) with subclinical myocardial ischemia in acute cardiac ischemia (ACI) patients. Methods: This prospective, observational study was conducted on 75 ACI patients referred to Golestan and Imam Khomeini hospitals of Ahvaz in 2023. The patients in healthy (CIMT≤0.8mm) and at risk of cardiac ischemia (CIMT>0.8mm) groups underwent carotid Doppler ultrasound to check CIMT and the presence of carotid plaque. Results: CIMT mean was 1.07±0.12 mm in healthy ACI patients and 1.4±0.19 mm in those at risk of cardiac ischemia. Among patients at risk of CIMT and carotid plaque, 85.1% and 80.8% had at least one cardiovascular risk factor, respectively. However, no significant differences were found between CIMT, carotid plaque, and patients' risk factor profiles (P = 0.129 vs. P = 0.515). The adjusted odds ratio (OR) for CIMT was 1.50 (95% CI: 0.58-3.94, P = 0.400), indicating no significant association with the outcome. No significant associations were observed for age, sex, diabetes, hypertension, LDL, or HDL. While the prevalence of vessel disease was higher in at-risk group than healthy CIMT group, no dramatic differences were observed between CIMT and vessel involvement (P = 0.136). Conclusion: The presence of one or more cardiovascular risk factors combined with increased CIMT may increase heart attack susceptibility, highlighting the potential of CIMT as an effective screening tool for predicting coronary artery disease. Further large-scale studies are needed to define its role in clinical practice more definitively.
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Shafiei et al. (2026) conducted an observational in Acute cardiac ischemia (n=75). Increased Carotid intima-media thickness (CIMT >0.8mm) vs. Normal CIMT (CIMT ≤0.8mm) was evaluated on Subclinical myocardial ischemia (angiographic vessel involvement) (OR 1.50, 95% CI 0.58-3.94, p=0.400). Increased carotid intima-media thickness (CIMT >0.8mm) did not demonstrate a statistically significant association with angiographic vessel involvement in patients with acute cardiac ischemia (OR 1.50, P=0.400).
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