Answers are grounded in this paper and cite their sources.
BACKGROUND/AIM: Colorectal cancer (CRC) remains the leading cause of cancer-related mortality worldwide and necessitates the development of novel therapeutic strategies. The tumor immune microenvironment (TME) critically influences disease progression and the response to immune checkpoint inhibitors (ICIs). Tumor-infiltrating lymphocytes (TILs) are key components of the TME with established prognostic and predictive significance. Nevertheless, detailed TIL characterization using flow cytometry has not been fully investigated in CRC. MATERIALS AND METHODS: We analyzed TILs from 90 fresh CRC specimens using multicolor flow cytometry to investigate the association between specific T cell subsets and clinical outcomes. Patients were classified into Hot and Cold groups based on hierarchical clustering of TIL marker expression. CONCLUSION: T cells is associated with better survival in CRC, highlighting their potential as a prognostic biomarker and therapeutic target.
No takes yet. Share an insight, caveat, or question.
Matoba et al. (2026) studied this question.