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Demonstrates efficient synthesis of diverse aryl-glucals, indicating broader applicability.
-aryl-glucals is achieved via Pd-catalyzed cross-coupling of readily accessible glucal 3-O-trichloroacetimidates with aryl boronic acids under mild conditions. The reaction features excellent β-selectivity, broad substrate scope, and scalability, and enables concise synthesis of dapagliflozin analogues. A plausible mechanism is also proposed.
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Chen et al. (2026) studied this question.
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