Blue rubber bleb nevus syndrome is a rare congenital vascular malformation disease characterized by venous malformations affecting multiple organs throughout the body. Cases complicated with esophageal cancer are exceedingly uncommon. In April 2025, Sir Run Run Shaw Hospital, affiliated with Zhejiang University School of Medicine, admitted a patient with blue rubber bleb nevus syndrome complicated with esophageal cancer. The patient was treated using da Vinci robotic-assisted surgery. This system may provide a new solution for such complex cases due to its precision and minimally invasive capabilities.
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Pan et al. (2026) studied this question.
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