Case demonstrates challenges in managing gastrointestinal bleeding in adults with late-onset blue rubber bleb nevus syndrome, suggesting surgery may be beneficial.
This case describes a 68-year-old man with recurrent gastrointestinal bleeding who was ultimately diagnosed with blue rubber bleb nevus syndrome with small-bowel predominance. Ongoing bleeding persisted despite multiple endoscopic interventions and medical therapy with sirolimus and octreotide, necessitating small-bowel resection. This case underscores the challenges in managing refractory gastrointestinal bleeding in adult late-onset blue rubber bleb nevus syndrome and highlights the potential role of early surgical intervention. The patient's sustained postoperative resolution of symptoms supports consideration of small-bowel resection in selected patients with small-bowel–predominant disease who fail endoscopic and medical therapies.
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Pilon et al. (2026) studied this question.
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