What question did this study set out to answer?

Assess the comparative effects of modified-release hydrocortisone versus conventional glucocorticoids in adrenal insufficiency.

May 1, 2026

Metabolic Effects of Modified-Release Hydrocortisone Versus Short Acting Conventional Oral Glucocorticoids in Adrenal Insufficiency: A Systematic Review and Meta-Analysis.

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Systematic review finds modified-release hydrocortisone improves metabolic outcomes in adrenal insufficiency, suggesting better treatment options.

Assess the comparative effects of modified-release hydrocortisone versus conventional glucocorticoids in adrenal insufficiency.
Systematic review and meta-analysis of comparative articles published until July 2025.
Primary outcomes included glucose metabolism, anthropometrics, lipid profile, and blood pressure.
Included six studies with a total of 400 participants.
MR-HC was associated with significant reductions in BMI (-1.1, 95% CI -2.11 to -0.1) and waist circumference (-5.03, 95% CI -8.54 to -1.51).
Total cholesterol decreased with MR-HC by -10.64 (95% CI -19.86 to -1.42) and systolic blood pressure by -6.03 (95% CI -10.95 to -1.1).
Bone health measures favored MR-HC with lumbar spine T-score (0.69, 95% CI 0.16 to 1.22) showing improvement.

Abdelsattar et al. (2026) studied this question.

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Systematic review finds modified-release hydrocortisone improves metabolic outcomes in adrenal insufficiency, suggesting better treatment options.