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This study aims to explore the anti-aging effects of Codonopsis pilosula polysaccharides and their impact on gut microbiota dysbiosis.

Codonopsis pilosula Polysaccharide (CPP) Alleviates D-Gal-Induced Aging and Gut Microbiota Dysbiosis

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This study aims to explore the anti-aging effects of Codonopsis pilosula polysaccharides and their impact on gut microbiota dysbiosis.
Used a D-galactose-induced aging mouse model to assess CPP's effects on cognitive deficits and aging markers.
Performed transcriptomic and metabolomic analyses to investigate the underlying mechanisms of CPP.
Conducted 16S rRNA sequencing to evaluate gut microbiota diversity after CPP treatment.
CPP improved cognitive deficits and reduced aging markers including p53, p21, and p16.
Demonstrated anti-inflammatory effects via the MAPK pathway, with significant regulation of inflammation-related genes (exact values not provided).
Restored gut microbiota diversity, indicating a positive impact on gut health.

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Randomized trial demonstrates anti-aging effects in mice, suggesting gut health improvement through intervention.

Zhang et al. (2026) studied this question.

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