Shows improved cancer cell death in hepatocellular carcinoma, suggesting a novel therapy approach.
levels and labile iron pools. Due to the combination of classical GPX4 suppression pathway by ROS with a non-classical HO-1-mediated iron overload mechanism for ferroptosis, the LHNPs@RBCM effectively killed cancer cells in both cellular and animal models. The excellent therapeutic effect of LHNPs@RBCM demonstrated it as a transformative strategy for clinical ferroptosis-based therapy.
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Wáng et al. (2026) studied this question.
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