Systematic review and meta-analysis demonstrates reduced mortality with early antibiotic de-escalation in febrile neutropenia, indicating safety in hematologic malignancies.
infection (CDI). In conclusion, early de-escalation of BSA in patients with hematologic malignancies and developing FN after treatment significantly reduces mortality risk without increasing major adverse events. These findings support the use of early de-escalation and highlight the need for personalized strategies to improve patient outcomes.
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