Prevalence and outcome of dual aortic stenosis and cardiac amyloid pathology in patients referred for transcatheter aortic valve implantation
Why the study?
Cardiac amyloidosis is common in elderly patients with aortic stenosis referred for TAVI, but whether dual AS-amyloid pathology affects baseline characteristics, periprocedural complications, and mortality was uncertain.
Does TAVI yield similar periprocedural and mortality outcomes in patients with dual AS-amyloid compared to lone AS?
Comparison
Dual aortic stenosis and cardiac amyloid pathology vs lone aortic stenosis
Design
Two-site prospective cohort study with blinded bone scintigraphy
Follow-up
Median of 19 (10-27) months
Authors
Discussion
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Member takes
Implication
TAVI in patients with concurrent severe aortic stenosis and cardiac amyloidosis yields similar mortality and periprocedural complication rates as in those with lone aortic stenosis, suggesting these patients should not be denied TAVI.
Structured PICO
Does TAVI yield similar periprocedural and mortality outcomes in patients with dual AS-amyloid compared to lone AS?
P
Population
200 patients aged ≥75 with severe aortic stenosis referred for transcatheter aortic valve implantation (TAVI) at two sites, mean age 85 ± 5 years, 50% male.
I
Intervention
Transcatheter aortic valve implantation (TAVI) in patients with dual aortic stenosis and cardiac amyloid pathology (AS-amyloid)
C
Comparator
Transcatheter aortic valve implantation (TAVI) in patients with lone aortic stenosis
O
Outcome
Periprocedural complications and mortality at median 19 months follow-uphard clinical
TAVI in patients with concurrent severe aortic stenosis and cardiac amyloidosis yields similar mortality and periprocedural complication rates as in those with lone aortic stenosis, suggesting these patients should not be denied TAVI.
Cite This Study
Scully et al. (2020) studied this question.