Why the study?
Does MMP inhibition attenuate LV remodeling and dysfunction in a rat model of progressive heart failure?
Population
60 rats total, including obese male spontaneously hypertensive heart failure rats and normotensive…
Comparison
MMP inhibitor PD166793 5 mg/kg/d PO administered… vs Untreated SHHF rats and normotensive WF rats.
Design
Preclinical
Follow-up
4 months (from 9 to 13 months of age)
Authors
Loading...
May attenuate LV remodeling in rodent HF; leaves open clinical translation.
Does MMP inhibition attenuate LV remodeling and dysfunction in a rat model of progressive heart failure?
Direct MMP inhibition attenuates left ventricular dilation and progression to dysfunction in a rodent model of progressive heart failure.
Peterson et al. (2001) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: