Population
Human left ventricular myocardium samples from patients with idiopathic end-stage dilated cardiomyopathy and…
Design
Case-control
Authors
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Increased MMP activity in end-stage DCM supports MMP inhibition as a target; hypothesis-generating and requires prospective trials before clinical consideration.
End-stage dilated cardiomyopathy is associated with increased matrix metalloproteinase activity and selective upregulation of specific MMPs and TIMPs in the left ventricular myocardium, suggesting a potential therapeutic target.
Thomas et al. (1998) studied this question.
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