May 11, 2009Circulation

Diagnosis of Acute Aortic Dissection by D-Dimer

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Why the study?

Does D-dimer testing reliably rule out acute aortic dissection in patients with suspected aortic dissection?

Population

220 patients with initial suspicion of having acute aortic dissection

Comparison

D-dimer testing (cutoff level of 500 ng/mL) vs Final clinical diagnosis

Design

Cohort

Follow-up

24 hours

Authors

TSToru SuzukiVascular Medicine ADA. DistanteHôpital Cochin AZAntonella ZizzaIstituto di Fisiologia Clinica

Discussion

Member takes

Implication

Supports D-dimer <500 ng/mL for ruling out aortic dissection within 24 h; leaves open prospective validation before routine adoption.

Structured PICO

Does D-dimer testing reliably rule out acute aortic dissection in patients with suspected aortic dissection?

Population

220 patients with initial suspicion of having acute aortic dissection (87 diagnosed with acute aortic dissection and 133 with other final diagnoses including myocardial infarction, angina, pulmonary embolism, and other uncertain diagnoses)

Intervention

D-dimer testing (cutoff level of 500 ng/mL)

Comparator

Final clinical diagnosis (acute aortic dissection vs. other diagnoses)

Outcome

Diagnostic performance (negative likelihood ratio) of D-dimer for ruling out acute aortic dissection within the first 24 hourssurrogate

D-dimer testing using a 500 ng/mL cutoff is a highly effective rule-out marker for acute aortic dissection when used within the first 24 hours of symptom onset.

Cite This Study

Suzuki et al. (2009) studied this question.

synapsesocial.com/papers/69f53fabb76c9a4576d8d0dc https://doi.org/10.1161/circulationaha.108.833004

View Full Paper

Ask AI

Bookmark

Diagnosis of Acute Aortic Dissection by D-Dimer

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Diagnosis of Acute Aortic Dissection by D-Dimer

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider