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January 25, 2006European Heart Journal

Prognostic value of circulating pregnancy-associated plasma protein levels in patients with chronic stable angina

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Why the study?

Does plasma PAPP-A level predict future death, ACS, and revascularization in patients with chronic stable CAD?

Population

103 patients referred for coronary angiography with chronic stable coronary artery disease, mean age 65+/-10…

Design

Cohort

Follow-up

median 4.9 years

Authors

AEAhmad A. ElesberMayo Clinic

Discussion

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Implication

May refine prognosis in stable CAD; hypothesis-generating and requires prospective validation before clinical use.

Structured PICO

Does plasma PAPP-A level predict future death, ACS, and revascularization in patients with chronic stable CAD?

P

Population

103 patients referred for coronary angiography with chronic stable coronary artery disease (stable symptoms for at least 6 weeks and coronary angiogram showing at least a 50% luminal diameter narrowing), mean age 65+/-10 years

I

Intervention

Measurement of plasma pregnancy-associated plasma protein (PAPP-A) level

O

Outcome

Incidence of death, acute coronary syndrome (ACS), and revascularizationhard clinical

Elevated plasma PAPP-A levels independently predict the occurrence of death and acute coronary syndrome in patients with chronic stable coronary artery disease.

Cite This Study

Ahmad A. Elesber (2006) studied this question.

synapsesocial.com/papers/69f53fbcb76c9a4576d8d121 https://doi.org/10.1093/eurheartj/ehl042

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Morphological characteristics of clinically significant coronary artery stenosis in stable angina.1986 · 125 citations
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4Intravascular Ultrasound Analysis of Infarct-Related and Non–Infarct-Related Arteries in Patients Who Presented With an Acute Myocardial Infarction2003 · 208 citations
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