November 11, 2003Circulation
Intravascular Ultrasound Assessment of Ulcerated Ruptured Plaques
Why the study?
Does IVUS assessment identify morphological differences between culprit ruptured plaques in ACS patients and nonculprit or non-ACS ruptured plaques?
Population
74 patients with 80 plaque ruptures (54 ACS patients and an unspecified number of non-ACS patients)
Comparison
Intravascular ultrasound assessment of culprit… vs IVUS assessment of nonculprit lesions in ACS…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
IVUS features may help identify culprit ACS ruptures; hypothesis-generating and should not yet change practice.
Structured PICO
Does IVUS assessment identify morphological differences between culprit ruptured plaques in ACS patients and nonculprit or non-ACS ruptured plaques?
P
Population
74 patients with 80 plaque ruptures (54 ACS patients and an unspecified number of non-ACS patients)
I
Intervention
Intravascular ultrasound (IVUS) assessment of culprit lesions in ACS patients (n=35)
C
Comparator
IVUS assessment of nonculprit lesions in ACS patients (n=19) and lesions in non-ACS patients (n=26)
O
Outcome
Morphological characteristics of plaque ruptures including presence of thrombus, minimal lumen area, area stenosis, plaque burden, lesion length, and remodeling indexsurrogate
Ruptured plaques in culprit lesions of ACS patients are characterized by smaller lumens, greater plaque burdens, and more frequent thrombus compared to nonculprit or non-ACS ruptured plaques.
Cite This Study
Fujii et al. (2003) studied this question.