Electroanatomic Left Ventricular Mapping in the Porcine Model of Healed Anterior Myocardial Infarction
Why the study?
Does electroanatomic mapping during sinus rhythm accurately characterize infarct architecture compared to pathology and ICE in a porcine model of healed anterior myocardial infarction?
Population
12 adult pigs
Comparison
Electroanatomic mapping during sinus rhythm vs Pathological measurements and intracardiac echo
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Voltage thresholds may delineate infarct in porcine models; leaves open human validation for electroanatomic mapping.
Structured PICO
Does electroanatomic mapping during sinus rhythm accurately characterize infarct architecture compared to pathology and ICE in a porcine model of healed anterior myocardial infarction?
P
Population
12 adult pigs (5 normal pigs and 7 pigs 6 to 10 weeks after left anterior descending coronary artery infarction)
I
Intervention
Electroanatomic mapping (CARTO, Biosense) during sinus rhythm
C
Comparator
Pathological measurements (exclusion of triphenyltetrazolium chloride staining) and intracardiac echo (ICE)
O
Outcome
Characterization of electrograms in normal and infarcted tissue and correlation of infarct size by electroanatomic mapping with pathology and ICEsurrogate
Electroanatomic mapping during sinus rhythm accurately characterizes 3D infarct architecture, correlating strongly with pathological and echocardiographic measurements in a porcine model.
Cite This Study
Callans et al. (1999) studied this question.