May 1, 2000Cardiovascular ResearchOpen Access

Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling

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Why the study?

Can modulation of matrix metalloproteinase (MMP) activity alter ventricular remodeling and the progression of heart failure?

Population

Failing human heart and experimental models of heart failure

Design

Review

Authors

YLYu LiTongji University

Discussion

Member takes

Implication

MMP modulation in heart failure remains investigational; leaves open whether targeted inhibition improves clinical outcomes.

Structured PICO

Can modulation of matrix metalloproteinase (MMP) activity alter ventricular remodeling and the progression of heart failure?

Population

Failing human heart and experimental models of heart failure

Intervention

Modulation of matrix metalloproteinase (MMP) activity (e.g., using gene transfer, knockout technologies, and anti-MMP strategies)

Outcome

Ventricular remodeling, myocardial dysfunction, and progression of heart failure

This review highlights the critical role of matrix metalloproteinases and their regulators in cardiac remodeling, suggesting that targeting MMP activity could be a viable strategy to prevent or reverse myocardial fibrosis in heart failure.

Cite This Study

Yu Li (2000) studied this question.

synapsesocial.com/papers/69f53fdbb76c9a4576d8d183 https://doi.org/10.1016/s0008-6363(00)00003-1

View Full Paper

Ask AI

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Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider