March 8, 2025Journal of the American Society of Echocardiography9 citationsOpen Access

Transaortic Flow Rate and Risk Stratification in Moderate Aortic Stenosis

PSPaolo SpringhettiCardiac Imaging MTMichele TomaselliCardiac Imaging LPLeonardo PortolanUniversity of Oxford

Structured PICO

Does impaired transaortic flow rate (< 218 mL/sec) predict adverse outcomes in patients with moderate aortic stenosis?

Population

Patients with moderate aortic stenosis (AS)

Intervention

Transaortic flow rate (FR) < 218 mL/sec

Outcome

Composite of all-cause mortality and hospitalization for heart failure (HHF)composite

In patients with moderate aortic stenosis, a transaortic flow rate < 218 mL/sec is an independent predictor of all-cause mortality and heart failure hospitalization.

Abstract

BACKGROUND: While left ventricular stroke volume (SV) is commonly used to define flow status in patients with aortic valve stenosis (AS), flow rate (FR) serves as a more precise descriptor of blood flow. However, evidence regarding the prognostic significance and determinates of transaortic FR, specifically in patients with a moderate AS, is limited. OBJECTIVES: We aimed to evaluate the association of transaortic FR with outcomes in patients with moderate AS. METHODS: ). The primary study end point was a composite of all-cause mortality and hospitalization for heart failure (HHF). RESULTS: < 218 mL/sec turned out to be independently associated with events (adjusted hazard ratio, 2.17 95% CI, 1.14-4.12, P = .018). CONCLUSIONS: < 218 mL/sec is independently associated with adverse outcomes in moderate AS. Further research is needed to determine whether patients with moderate AS and impaired transaortic FR would benefit from more intensive monitoring or earlier aortic valve replacement.

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Cite This Study

Springhetti et al. (Sat,) studied this question.

synapsesocial.com/papers/69f54008b76c9a4576d8d1fa https://doi.org/https://doi.org/10.1016/j.echo.2025.02.017

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