Associations between maternal smoking around birth and hepatocellular carcinoma: A bidirectional two sample Mendelian randomization study in East Asian populations
Randomized trial investigates maternal smoking effects on hepatocellular carcinoma risk in East Asian offspring, suggesting significant associations.
Key Points
This study investigates the association between maternal smoking around birth and the risk of hepatocellular carcinoma in offspring from East Asian populations.
Utilized genome-wide association study data from the UK Biobank and Biobank Japan.
Conducted two-sample Mendelian randomization using single-nucleotide polymorphisms as instrumental variables.
Employed multiple MR approaches: inverse-variance weighting, weighted median estimation, and MR-Egger regression.
Identified 113 SNPs significantly associated with maternal smoking around birth.
Positive association found between maternal smoking and increased HCC risk in offspring (IVW: OR=1.06; 95% CI: 1.05-1.07).
No evidence indicating HCC affects maternal smoking patterns, suggesting a direct influence.