Based on the characteristics of curcumin, such as low bioavailability, low toxicity, wide availability, and multiple biological activities, and in conjunction with its established pharmacological effects on anti-platelet activation, aggregation inhibition, and platelet count enhancement, the following hypothesis is proposed: Curcumin may exert therapeutic effects in multiple systems, including cardiovascular, neurological, digestive, musculoskeletal, and genitourinary systems, by modulating platelet function and its derived factors, thereby interfering with various disease-related pathways. In light of this, the present study aims to address the following questions: Through which specific molecular pathways and mechanisms does curcumin regulate platelets and their derived factors, thereby exerting therapeutic effects on diseases in different systems? Additionally, this research seeks to provide a theoretical foundation for further exploration of novel therapeutic directions for curcumin in disease treatment.
Li et al. (Thu,) studied this question.