Comparative Efficacy and Safety of Osteobiologics in Posterior Lumbar Fusion: A Network Meta-Analysis of Randomized Controlled Trials.

Key Points

• The research aims to evaluate the efficacy and safety of different osteobiologics in posterior lumbar fusion surgeries.
• Conducted a network meta-analysis of randomized controlled trials comparing various osteobiologics.
• Analyzed treatment outcomes including efficacy and safety among different agents.
• Included various studies that evaluated the use of rhBMP-2 and AICBG.
• rhBMP-2 showed superior efficacy and safety compared to AICBG, with a p-value of 0.002.
• Other osteobiologic agents indicated favorable trends, but without statistical significance.
• No treatment reduced length of stay (LOS) significantly.