This research aims to investigate the mechanism of PrP unfolding as a precursor to its refolding, particularly in the context of PrP<sup>Sc</sup> propagation.
Analyzed the atomistic structure of PrP
Examined the transition from PrP<sup>C</sup> to PrP<sup>Sc</sup>
Assessed the conditions affecting PrP refolding
Identified specific structural changes in PrP<sup>C</sup> during unfolding.
Found that certain conditions facilitate the refolding of PrP<sup>C</sup> into PrP<sup>Sc</sup>.
Demonstrated a correlation between unfolding states and increased PrP<sup>Sc</sup> propagation.
Abstract
It might have been believed that elucidation of the atomistic structure of PrP
Ask AI
Helpful
Bookmark
Share
View Full Paper
Cite This Study
Sabzehei et al. (2026) studied this question. PrPC unfolding is a critical step that precedes its refolding during the propagation of PrPSc.