Demonstrates the anxiolytic and memory protective effects of withanolide D in zebrafish, indicating its therapeutic potential.
receptor, supporting a putative allosteric interaction in a functionally related modulatory region rather than definitive occupation of the classical diazepam site. Consistently, normal mode analysis (NMA) showed that withanolide D increases receptor mobility compared to diazepam, with RMSF values reaching up to 0.98 Å, indicating enhanced structural flexibility and dynamic modulation of the protein. Thus, these findings suggest that withanolide D has therapeutic potential for the treatment of anxiety, in addition to providing protective effects on memory.
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Feitosa et al. (2026) studied this question.
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