Reveals contributions of TRPML1 to neuropathic pain in diabetic peripheral neuropathy, suggesting lysosomal channels as potential targets.
ARTICLE HIGHLIGHTS: A lysosomal ion channel, TRPML1, contributes to neuropathic pain associated with diabetic peripheral neuropathy (DPN). TRPML1 of dorsal root ganglion neurons contributes to type 2 DPN pain. Astrocyte TRPML1 contributes to type 1 DPN pain. Lysosomal ion channels may be novel mechanisms and targets for DPN pain.
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Yang et al. (2026) studied this question.
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