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April 28, 2026ChemistrySelect

An Efficient Synthesis of New N ‐Aryl‐ N '‐Acyl Thiourea Derivatives and Their Antimicrobial Activity, Cytotoxicity, and In Silico Studies

Nilesh Sakhare Prasanna Joshi Manish Bhoye Kiran Kharad Pravin Mhaske Sushma Takate Sadhana Mhaske

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Key Points

The study aims to synthesize and evaluate the antimicrobial and cytotoxic properties of new N-aryl-N'-acyl thiourea derivatives.
Synthesis using PEG-SO3H catalyst.
In vitro evaluation of antimicrobial activity against fungal strains A. niger and C. albicans.
Cytotoxicity screening against A549 and MCF-7 cell lines.
Compounds 4b and 4f showed antifungal activity comparable to fluconazole with MIC of 15.62 µg/mL against A. niger.
Compounds 4j and 4k showed MICs of 31.25 µg/mL against C. albicans.
Compounds 4g, 4k, and 4m exhibited excellent cytotoxicity against MCF-7 with IC50 of 2.17, 30.48, and 15.67 µM, respectively.

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Implication

Evaluates antimicrobial and cytotoxic properties of new N-aryl-N'-acyl thiourea derivatives, suggesting potential medicinal uses.

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Cite This Study

Sakhare et al. (2026) studied this question.

synapsesocial.com/papers/69f5947e71405d493afff569 https://doi.org/10.1002/slct.202506812

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