A novel yeast extract from a multi-stress-resistant Saccharomyces cerevisiae confers potent antioxidant and UV-protective activities to skin cells.

) after UVA irradiation. Further analysis of functional components in yeast extracts from the A154 and parental strains revealed an approximately 1.5-fold increase in glutathione and a 1.6-fold increase in polysaccharides. Additionally, whole-genome sequencing coupled with functional validation using knockout strains identified multiple previously uncharacterized genes in the A154 strain that are unrelated to DNA repair and contribute to UVA tolerance. In conclusion, yeast extract derived from A154 exhibits potent UV-protective and antioxidant activities, highlighting its potential applications in mitigating photoaging and UV-induced skin damage.