RUNX2 drives adenoma-to-carcinoma transition in colon cancer.

Jin Wu; Kaiyu Shen; Qi Tang; Fan Dong; Zhouyue Gu; Junhao Wu; Xijin Wu; Jiayi He; Zhenhui Zhang; Jie Liu; Bo Fu; Jieya Chen; Yingzi Hu; Ping Ling; Yanxuan Hu; Yu Song; X Liu; Morong Wu; Huiying Fu; Yingchao Liu

doi:10.1038/s41419-026-08801-2

Key Points

The research aims to clarify how RUNX2 contributes to the transition from adenoma to carcinoma in colon cancer.
Examined the role of RUNX2 in malignant epithelial progenitor cells (EPCs).
Investigated TNF-α binding to TNFRSF1A.
Analyzed the impact on adenoma-to-carcinoma transition.
RUNX2 activation is linked to increased adenoma-to-carcinoma transition.
TNF-α binding to TNFRSF1A enhances RUNX2 activation, contributing to poor prognosis.

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Implication

Shows RUNX2 activation promotes adenoma-to-carcinoma transition in colon cancer, suggesting implications for prognosis.

Abstract

Tex cells may activate RUNX2 in malignant EPCs through TNF-α binding to TNFRSF1A, promoting the adenoma-to-carcinoma transition and contributing to poor prognosis.

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Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/69f594b171405d493afff859 https://doi.org/10.1038/s41419-026-08801-2

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RUNX2 drives adenoma-to-carcinoma transition in colon cancer.

Key Points

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Implication

Abstract

Discussion

Cite This Study

RUNX2 drives adenoma-to-carcinoma transition in colon cancer.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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