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May 2, 2026

The environmental stress response regulates biophysics of the cytoplasm and survival in quiescence.

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Authors

LKLorena KronigCWCarmen A. WeberPGPablo Aurelio Gómez-García

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Overview

Randomized trial demonstrates survival in quiescent yeast by regulating cytoplasmic properties and respiration, indicating adaptive mechanisms.

Key Points

  • The aim is to investigate how environmental stress responses influence yeast survival and cytoplasmic biophysics during quiescence.
  • Examined the effects of respiration and glucose withdrawal in budding yeast.
  • Analyzed gene expression and proteomic changes during quiescence adaptation.
  • Studied the role of Ras/PKA in the environmental stress response and cytoplasmic diffusion modulation.
  • Respiration is essential for initiating an adaptive program unique to quiescence, enhancing survival.
  • Preemptive induction of the quiescence program allows cells to survive without respiration, restoring biophysical properties.
  • Proteomic adaptations triggered by Ras/PKA inactivation and Msn2/4 activation significantly affect cytoplasmic diffusion.

Cite This Study

Kronig et al. (2026) studied this question.

synapsesocial.com/papers/69f594ca71405d493afffaeahttps://doi.org/10.1083/jcb.202601119
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