Demonstrates a novel synthesis method for clerodane diterpenoids, suggesting a general blueprint for similar compounds.
-decalin core. Subsequent Stille coupling and ketalization enabled the assembly of the complete carbon skeleton. During the reductive ring-opening of the isoxazoline moiety, unexpected epimerization at C6 was observed, enabling a divergent synthetic strategy. This streamlined strategy may serve as a general blueprint for the synthesis of other members of the clerodane diterpenoid family.
No takes yet. Share an insight, caveat, or question.
Zhao et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: