Demonstrates that TLR7 alters maternal immune responses, increasing morbidity in mothers and fetuses during influenza A infection, highlighting potential therapeutic targets.
mice showed improved body weight and reduced placental and fetal brain inflammation compared to WT counterparts. We provide evidence that TLR7 is a critical mediator of adverse pregnancy outcomes during IAV infection and a potential therapeutic target to reduce maternal and fetal morbidity.
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Trollope et al. (2026) studied this question.
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