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April 30, 2026

Complete de novo assembly of Wolbachia endosymbiont of contemporary Drosophila simulans using long-read genome sequencing.

Jodie Jacobs Alexandra Lum Elyse Mina Camryn N. Morey Darren Lee Emry Gutierrez Jonah Dionisio Cade Mirchandani Luke Sylvester Anne Nakamoto Hailey Loucks Ciara Wanket Ariana Cisneros Alessandro Calicchio Alexis Enstrom Camille Headrick Faith Okamoto H. D. Heath Kseniya Malukhina P. E. Russell Sagorika Nag Thomas Gillespie William Sobolewski Zia Truong Shelbi L. Russell

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Key Points

To achieve a complete de novo assembly of the Wolbachia endosymbiont genome present in Drosophila simulans.
Long-read genome sequencing was utilized for more accurate genome assembly.
Embryos were collected for genomic analysis during October 2023 at UC Santa Cruz.
The assembly provides comprehensive insights into the genetic makeup of Wolbachia.
Findings suggest evolutionary adaptations of the endosymbiont in the Drosophila simulans lineage.

Implication

Demonstrates the genetic structure of Wolbachia endosymbiont in Drosophila simulans, suggesting evolutionary implications.

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Cite This Study

Jacobs et al. (2026) studied this question.

synapsesocial.com/papers/69f594e171405d493afffd53 https://doi.org/10.1128/mra.00992-25

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Complete de novo assembly of Wolbachia endosymbiont of Drosophila willistoni using long-read genome sequencing2024 · 1 citations
2Complete de novo assembly of Wolbachia endosymbiont of Drosophila willistoni using long-read genome sequencing2024 · 7 citations
3<i>De novo</i> whole-genome assembly of the <i>Wolbachia</i> sp. endosymbiont from <i>Anastrepha fraterculus</i> using long- and short-read metagenomic dataOriginal Research · 2026
4Single-fly genome assemblies fill major phylogenomic gaps across the Drosophilidae Tree of Life2024 · 67 citations
5The mosaic genome structure of the <i>Wolbachia w</i> Ri strain infecting <i>Drosophila simulans</i>Original Research · 2009 · 242 citations

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