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Research finds how antimicrobials bind to the 30S ribosomal subunit in bacteria, suggesting design improvements.
ribosomal 30S small subunit. For this, we used structural analogy, restrained energy minimization, and single-point binding free energy computations. We find the single-point binding free energy of the MIAs to be very sensitive to small conformational changes in the MIA and its environment. Incorporating this knowledge in structure-guided design could aid in the development of narrow-spectrum MIAs targeting specific bacterial pathogens.
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Manjari et al. (2026) studied this question.
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