What question did this study set out to answer?

This work aims to design and evaluate new imidazole-based tetrapeptides as effective antibacterial agents against resistant Staphylococcus aureus strains.

May 7, 2026Journal of Peptide Science

Rational Design and Biological Evaluation of Imidazole‐Based Tetrapeptides as Antibacterial Leads Against Staphylococcus aureus

View Full Paper

Ask AI

Bookmark

Authors

MSMohammed Sharif ShaikVignan's Foundation for Science, Technology & Research VJVidya Sagar JerraVignan's Foundation for Science, Technology & Research BRBalajee RamachandranBoston University

Discussion

Member takes

Implication

Randomized trial evaluates antibacterial effects of imidazole-based tetrapeptides in combating resistant Staphylococcus aureus, indicating promising leads for drug development.

Key Points

This work aims to design and evaluate new imidazole-based tetrapeptides as effective antibacterial agents against resistant Staphylococcus aureus strains.
125 imidazole-based tetrapeptides designed and evaluated in silico and in vitro.
Molecular docking studies used to assess binding energies against MRSA.
Compounds synthesized and screened for antibacterial activity via minimum inhibitory concentration and time-kill assays.
Compound C showed the lowest MIC of 29.8 ± 4.2 μg/mL against MRSA.
Compound C demonstrated bactericidal activity against MSSA and MRSA, and bacteriostatic against VRSA.
ADME predictions indicated favorable safety profiles with < 5% haemolysis.

Cite This Study

Shaik et al. (2026) studied this question.

synapsesocial.com/papers/69fc2c1f8b49bacb8b347cd5 https://doi.org/10.1002/psc.70098

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial evaluates antibacterial effects of imidazole-based tetrapeptides in combating resistant Staphylococcus aureus, indicating promising leads for drug development.

Rational Design and Biological Evaluation of Imidazole‐Based Tetrapeptides as Antibacterial Leads Against Staphylococcus aureus

Discussion

Member takes

Implication

Key Points

Cite This Study

Rational Design and Biological Evaluation of Imidazole‐Based Tetrapeptides as Antibacterial Leads Against Staphylococcus aureus

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider