Adenosine A₁ and A2A Receptors in Sleep Disorders: Mechanisms and Therapeutic Implications.

Hye Jin Jee; Cherin Youn; HaeUn Lee; Yi-Sook Jung

doi:10.4062/biomolther.2026.070

May 1, 2026

Adenosine A₁ and A2A Receptors in Sleep Disorders: Mechanisms and Therapeutic Implications.

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Key Points

This research examines the role of adenosine A1 and A2A receptors in various sleep disorders and their therapeutic potential.
Evaluated alterations in adenosine receptors in insomnia, obstructive sleep apnea, narcolepsy, and restless legs syndrome.
Assessed receptor-selective intervention strategies for treating these disorders.
Identified significant alterations in adenosine receptor activity in patients with insomnia and obstructive sleep apnea.
Highlighted potential therapeutic strategies targeting A1 and A2A receptors for improved treatment outcomes.

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Implication

Evaluates therapeutic potential of adenosine receptor-selective strategies for sleep disorders, suggesting new treatment avenues.

Abstract

receptor is altered in insomnia, obstructive sleep apnea, narcolepsy, and restless legs syndrome, and evaluates the therapeutic potential of receptor-selective strategies for adenosine receptor-targeted treatment.

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Jee et al. (2026) studied this question.

synapsesocial.com/papers/69f5955971405d493a000364 https://doi.org/10.4062/biomolther.2026.070

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Adenosine A₁ and A2A Receptors in Sleep Disorders: Mechanisms and Therapeutic Implications.

Key Points

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Implication

Abstract

Discussion

Cite This Study

Adenosine A₁ and A2A Receptors in Sleep Disorders: Mechanisms and Therapeutic Implications.

Key Points

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Implication

Abstract

Discussion

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