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September 22, 2006AnesthesiologyOpen Access

Quantifying the Effect of Antiplatelet Therapy

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Why the study?

Do point-of-care monitors (mTEG and PFA-100) accurately identify the antiplatelet effect of aspirin and clopidogrel compared to optical light transmission aggregometry?

Population

Patients taking aspirin (n=20) and/or clopidogrel

Comparison

Point-of-care platelet function monitoring using… vs Optical light transmission aggregometry

Design

Cross-sectional

Authors

SASeema AgarwalAssociation of Anaesthetists of Great Britain and IrelandMCMargaret CoakelyUniversity Hospital of WalesKRK. Ratna ReddyMediclinic City Hospital

Discussion

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Implication

Supports mTEG for POC antiplatelet monitoring; leaves open prospective outcome validation before clinical adoption.

Structured PICO

Do point-of-care monitors (mTEG and PFA-100) accurately identify the antiplatelet effect of aspirin and clopidogrel compared to optical light transmission aggregometry?

P
Population
Patients taking aspirin (n=20) and/or clopidogrel
I
Intervention
Point-of-care platelet function monitoring using modified thromboelastograph (mTEG) and platelet function analyzer (PFA-100)
C
Comparator
Optical light transmission aggregometry
O
Outcome
Identification of antiplatelet effect compared to aggregometrysurrogate

Modified thromboelastography (mTEG) is an effective point-of-care monitor for detecting the antiplatelet effects of both aspirin and clopidogrel, outperforming the PFA-100 for clopidogrel.

Cite This Study

Agarwal et al. (2006) studied this question.

synapsesocial.com/papers/69f69049e405cc4465bc285fhttps://doi.org/10.1097/00000542-200610000-00011

Topics

Dual antiplatelet therapyPCSK9 inhibitorsStatin therapy
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effect of clopidogrel, aspirin and both antiplatelet drugs on platelet function in patients with peripheral arterial disease2004 · 64 citations
  2. 2Clopidogrel for Coronary Stenting2003 · 1,546 citations
  3. 3Monitoring Aspirin 1 00 mg and Clopidogrel 75 mg Therapy with the PFA-1 00 Device in Patients with Peripheral Arterial Disease2003 · 35 citations
  4. 4Platelet hyper-function in acute coronary syndromes2005 · 38 citations