February 1, 2002AJP Heart and Circulatory Physiology

Relationship between no reflow and infarct size as influenced by the duration of ischemia and reperfusion

View Full Paper

Ask AI

Bookmark

Population

Anesthetized, open-chest rabbit model of coronary artery occlusion and reperfusion

Design

Preclinical

Follow-up

Up to 180 minutes of reperfusion

Authors

TRThorsten ReffelmannForschungsinstitut für Mineralische und Metallische Werkstoffe Edelsteine/Edemetalle SHSharon L. HaleUniversity of Southern California LGLI Guo-huNorthwest A&F University

Discussion

Member takes

Implication

Infarct size may drive progressive no-reflow in animal reperfusion; leaves open clinical translation and therapeutic targeting.

Structured PICO

Population

Anesthetized, open-chest rabbit model of coronary artery occlusion and reperfusion (retrospective analysis of control groups from five previous protocols)

Intervention

Coronary artery occlusion (30 min or 120 min) followed by reperfusion

Outcome

Correlation between regional myocardial blood flow (RMBF) and infarct size in the course of reperfusionsurrogate

In a rabbit model of ischemia-reperfusion, infarct size is the major determinant of no-reflow, which progressively worsens during the first 2 hours of reperfusion.

Cite This Study

Reffelmann et al. (2002) studied this question.

synapsesocial.com/papers/69f69057e405cc4465bc2888 https://doi.org/10.1152/ajpheart.00767.2001

View Full Paper

Ask AI

Bookmark

Relationship between no reflow and infarct size as influenced by the duration of ischemia and reperfusion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Relationship between no reflow and infarct size as influenced by the duration of ischemia and reperfusion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider