Why the study?
AF and functional mitral regurgitation frequently coexist, but current evidence offers limited direction on the prioritization of treatment for these conditions.
Does rhythm control of AF reduce the severity of FMR in patients with newly diagnosed AF and concomitant high-grade FMR?
Does rhythm control of AF reduce the severity of FMR in patients with newly diagnosed AF and concomitant high-grade FMR?
Rhythm control of atrial fibrillation can significantly reduce the severity of concomitant high-grade functional mitral regurgitation, potentially eliminating the need for mitral valve intervention.
Answers are grounded in this paper and cite their sources.
May support rhythm control to avoid mitral intervention in AF; hypothesis-generating pending randomized confirmation.
BACKGROUND: Atrial fibrillation (AF) and functional mitral regurgitation (FMR) frequently coexist, presenting significant challenges for therapeutic management. Current evidence offers limited direction on the prioritization of treatment for these conditions. This study aims to evaluate the impact of rhythm control on high-grade FMR and identify predictors of persistent high-grade FMR after AF treatment. METHODS: This single-center study analyzed patients with newly diagnosed AF and concomitant high-grade FMR. Predictors of persistent high-grade FMR after rhythm control of AF were assessed by logistic regression. CONCLUSIONS: Rhythm control of AF significantly reduced the severity of FMR in most patients, eliminating the need for mitral valve (MV) intervention in these cases. The identified predictors of persistent high-grade FMR could contribute to refined risk assessment and assist in treatment decision-making, potentially supporting early referral for MV intervention in appropriate patients.
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Ausbuettel et al. (2025) studied this question.
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