Relation between Renal Dysfunction and Cardiovascular Outcomes after Myocardial Infarction
Why the study?
Does reduced estimated GFR increase the risk of mortality and cardiovascular events in patients with acute myocardial infarction complicated by heart failure or left ventricular dysfunction?
Population
14,527 patients with acute myocardial infarction complicated by clinical or radiologic signs of heart…
Comparison
Reduced estimated glomerular filtration rate vs Higher or normal estimated glomerular filtration…
Design
Cohort, Patients were randomly assigned to receive captopril, valsartan, or both
Authors
Discussion
Loading...
Member takes
Implication
Mild renal impairment may aid risk stratification after MI with HF or LV dysfunction; leaves open whether modifying eGFR alters outcomes.
Structured PICO
Does reduced estimated GFR increase the risk of mortality and cardiovascular events in patients with acute myocardial infarction complicated by heart failure or left ventricular dysfunction?
P
Population
14,527 patients with acute myocardial infarction complicated by clinical or radiologic signs of heart failure, left ventricular dysfunction, or both, and a documented serum creatinine measurement.
I
Intervention
Reduced estimated glomerular filtration rate (eGFR)
C
Comparator
Higher or normal estimated glomerular filtration rate
O
Outcome
Overall mortality and composite cardiovascular events (death from cardiovascular causes, reinfarction, congestive heart failure, stroke, or resuscitation after cardiac arrest)composite
Even mild renal impairment is a major independent risk factor for cardiovascular complications and mortality after myocardial infarction complicated by heart failure or LV dysfunction.
Cite This Study
Anavekar et al. (2004) studied this question.