June 15, 1996Circulation

Identification of a Potential Role for the Adventitia in Vascular Lesion Formation After Balloon Overstretch Injury of Porcine Coronary Arteries

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Population

Domestic juvenile swine

Design

Preclinical

Follow-up

14 days

Authors

NSNeal A. Scott GCGustavo D. CipollaUnited States Nuclear Regulatory Commission CRCheryl E. RossAmgen (United States)

Discussion

Member takes

Implication

Adventitial myofibroblasts may drive post-angioplasty remodeling in animals; leaves open human translation and therapeutic targeting.

Structured PICO

Population

Domestic juvenile swine

Intervention

Balloon overstretch injury to the left anterior descending and circumflex coronary arteries with standard percutaneous transluminal coronary angioplasty balloon catheters

Outcome

Onset of cell proliferation and growth factor expression (PDGF A-chain and beta-receptor mRNAs)surrogate

Adventitial myofibroblasts appear to contribute to vascular lesion formation and arterial remodeling after balloon angioplasty by proliferating, synthesizing growth factors, and migrating into the neointima.

Cite This Study

Scott et al. (1996) studied this question.

synapsesocial.com/papers/69f690b4e405cc4465bc2973 https://doi.org/10.1161/01.cir.93.12.2178

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Identification of a Potential Role for the Adventitia in Vascular Lesion Formation After Balloon Overstretch Injury of Porcine Coronary Arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of a Potential Role for the Adventitia in Vascular Lesion Formation After Balloon Overstretch Injury of Porcine Coronary Arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider