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March 2, 2020Heart Failure ReviewsOpen Access

Nutritional interventions for heart failure patients who are malnourished or at risk of malnutrition or cachexia: a systematic review and meta-analysis

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Why the study?

Malnutrition is common in HF and linked to higher readmission and mortality, but whether protein and energy supplementation improves outcomes remained uncertain.

Do nutritional interventions aiming to increase protein and energy intake improve outcomes in adult heart failure patients who are malnourished or at risk of malnutrition or cachexia?

Comparison

Protein or energy supplementation vs control or conventional treatment

Authors

DHDina HabaybehMMMariana Bordinhon de MoraesASAdrian Slee

Discussion

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Overview

May support weight gain via nutrition in malnourished HF; extends sparse trial data but leaves clinical outcome effects open.

Structured PICO

Do nutritional interventions aiming to increase protein and energy intake improve outcomes in adult heart failure patients who are malnourished or at risk of malnutrition or cachexia?

P
Population
Adult heart failure patients who are malnourished or at risk of malnutrition or cachexia (5 studies: 4 RCTs and 1 pilot RCT)
I
Intervention
Nutritional interventions aiming to increase protein and energy intake (protein or energy supplementation)
C
Comparator
Conventional treatment / control
O
Outcome
Body weight, triceps skinfold thickness, all-cause mortality, and hospital readmissionsurrogate

Nutritional interventions may improve body weight in malnourished heart failure patients, but larger, more robust studies are needed to confirm clinical benefits.

Limitations

  • Small study sizes
  • Limited quality of included studies
  • Poor strength of evidence

Cite This Study

Habaybeh et al. (2020) studied this question.

synapsesocial.com/papers/69f690c4e405cc4465bc29a7https://doi.org/10.1007/s10741-020-09937-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Self-Rating of Quality of Life Provides Additional Prognostic Information in Heart Failure. Insights into the EPICAL Study2002 · 184 citations
  2. 2The “Golden Age” of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants2017 · 24,496 citations
  3. 3Readmission and mortality in malnourished, older, hospitalized adults treated with a specialized oral nutritional supplement: A randomized clinical trial2016 · 475 citations
  4. 4Adequate Energy-Protein Intake is Not Enough to Improve Nutritional and Metabolic Status in Muscle-Depleted Patients with Chronic Heart Failure2008 · 119 citations
  5. 5Health related quality of life in patients with congestive heart failure: comparison with other chronic diseases and relation to functional variables2002 · 784 citations