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October 5, 2008European Journal of Heart Failure

Adequate Energy-Protein Intake is Not Enough to Improve Nutritional and Metabolic Status in Muscle-Depleted Patients with Chronic Heart Failure

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Why the study?

Does essential amino acid supplementation combined with adequate energy-protein intake improve nutritional, metabolic, and functional status in muscle-depleted patients with chronic heart failure?

Population

38 stable chronic heart failure patients with severe depletion of muscle mass, mean age 73.5+/-4 years, 27…

Comparison

Oral supplements of essential amino acids 8… vs No supplements, with adequate energy-protein…

Design

RCT, randomised

Follow-up

2 months

Authors

RARoberto AquilaniUniversity of PaviaCOCristina OpasichHeart Failure & TransplantAGAlessandra GualcoUniversity of Pavia

Discussion

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Overview

Supports supplementation in muscle-depleted HF; extends nutritional intervention evidence for functional gains.

Structured PICO

Does essential amino acid supplementation combined with adequate energy-protein intake improve nutritional, metabolic, and functional status in muscle-depleted patients with chronic heart failure?

P
Population
38 stable chronic heart failure (CHF) patients with severe depletion of muscle mass, mean age 73.5+/-4 years, 27 males, BMI 22.5+/-1.4 kg/m2.
I
Intervention
Oral supplements of essential amino acids 8 g/day added to adequate energy-protein intake (energy >=30 kcal/kg; proteins >1.1 g/kg) for 2 months.
C
Comparator
No supplements, with adequate energy-protein intake (energy >=30 kcal/kg; proteins >1.1 g/kg) for 2 months.
O
Outcome
Metabolic (plasma lactate, pyruvate concentration, serum insulin level, HOMA index), nutritional (nitrogen balance), and functional (exercise test, walking test) evaluations at 2 months.surrogate

Essential amino acid supplementation combined with adequate energy-protein intake improves body weight, metabolic profiles, and exercise capacity in muscle-depleted patients with chronic heart failure.

Cite This Study

Aquilani et al. (2008) studied this question.

synapsesocial.com/papers/69f690c4e405cc4465bc29b2https://doi.org/10.1016/j.ejheart.2008.09.002
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Also Consider

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  1. 1Evaluation of energy metabolism in skeletal muscle of patients with heart failure with gated phosphorus-31 nuclear magnetic resonance.1985 · 199 citations
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  4. 4SEPSIS-INDUCED ALTERATIONS IN PYRUVATE DEHYDROGENASE COMPLEX ACTIVITY IN RAT SKELETAL MUSCLE1996 · 136 citations
  5. 5Role of Leucine in Protein Metabolism During Exercise and Recovery2002 · 106 citations