Key result
Obesity is not linked to increased mortality in advanced HF but trends toward improved survival.
Why the study?
Previous reports link obesity to the development of HF, but the impact of obesity in patients with established HF had not been studied.
Does obesity increase mortality in patients with advanced heart failure?
Cohort (n=1,203)
Does obesity increase mortality in patients with advanced heart failure?
In patients with advanced heart failure, obesity is not associated with increased mortality and may confer a more favorable prognosis, supporting the concept of an obesity paradox in this population.
No takes yet. Share an insight, caveat, or question.
May not support aggressive weight loss in advanced HF; leaves open the obesity paradox for prospective validation.
Horwich et al. (2001) conducted a cohort in Advanced heart failure (n=1,203). Obesity (BMI >31) and Overweight (BMI 27.8-31) vs. Recommended BMI (20.7-27.7) and Underweight (BMI <20.7) was evaluated on Survival. Obesity (BMI >31) was not associated with increased mortality among 1,203 patients with advanced heart failure, but instead demonstrated a trend toward improved survival.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: