Key result
Class III obesity is linked to ~39% lower long-term mortality in non-ischemic HFpEF only.
Why the study?
Whether heart failure etiology modifies the obesity paradox in patients with HFpEF remains controversial.
Does obesity reduce all-cause death risk differently in HFpEF patients with ischemic versus non-ischemic etiology?
Observational (n=3,360)
Does obesity reduce all-cause death risk differently in HFpEF patients with ischemic versus non-ischemic etiology?
Hazard Ratio: 0.61 (95% CI 0.38–0.97)
The 'obesity paradox' in HFpEF is modified by heart failure etiology, persisting long-term in non-ischemic patients but disappearing in those with ischemic etiology.
No takes yet. Share an insight, caveat, or question.
Etiology may modify long-term obesity paradox in HFpEF; leaves open whether ischemic patients need distinct weight strategies.
Zeng et al. (2022) conducted an observational in Heart failure with preserved ejection fraction (HFpEF) (n=3,360). Obesity (assessed by body mass index) vs. Lower BMI categories was evaluated on Long-term all-cause death in non-ischemic HFpEF with class III obesity (HR 0.61, 95% CI 0.38-0.97). Class III obesity was associated with a lower risk of long-term all-cause death in non-ischemic HFpEF (HR 0.61; 95% CI 0.38-0.97), but this benefit disappeared in ischemic HFpEF.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: