Why the study?
Does amlodipine or lisinopril reduce the incidence of end-stage renal disease or significant GFR decline compared with chlorthalidone in high-risk hypertensive patients?
Population
31,897 hypertensive participants 55 years or older with at least 1 other coronary heart disease risk factor…
Comparison
Amlodipine or lisinopril for a mean of 4.9 years vs Chlorthalidone for a mean of 4.9 years
Design
RCT, randomized
Follow-up
mean 4.9 years
Authors
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Supports chlorthalidone as initial therapy for ESRD prevention in high-risk hypertension with reduced GFR; confirms comparable renal outcomes with amlodipine or lisinopril.
Does amlodipine or lisinopril reduce the incidence of end-stage renal disease or significant GFR decline compared with chlorthalidone in high-risk hypertensive patients?
In high-risk hypertensive patients, neither amlodipine nor lisinopril was superior to chlorthalidone in preventing ESRD or significant GFR decline.
Mahboob Rahman (2005) studied this question.
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