February 26, 2013American Journal of Medical Genetics Part AOpen Access

GenTAC registry report: Gender differences among individuals with genetically triggered thoracic aortic aneurysm and dissection

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Why the study?

Are there gender differences in clinical characteristics, surgical interventions, and medical therapy among individuals with genetically triggered thoracic aortic aneurysm and dissection?

Population

1,449 adults with genetically triggered thoracic aortic aneurysms and cardiovascular conditions, including…

Comparison

Female gender vs Male gender

Design

Cross-sectional

Authors

KHKathryn W. HolmesOregon Health & Science University CMCheryl L. MaslenOregon Health & Science University MKMark KindemResearch Triangle Park Foundation

Discussion

Member takes

Implication

Sex differences in aortic surgery and ACEi use should not change practice; leaves open whether size thresholds disadvantage women with heritable aortopathy.

Structured PICO

Are there gender differences in clinical characteristics, surgical interventions, and medical therapy among individuals with genetically triggered thoracic aortic aneurysm and dissection?

Population

1,449 adults with genetically triggered thoracic aortic aneurysms and cardiovascular conditions, including Marfan syndrome (MFS), familial thoracic aortic aneurysm or dissection (FTAAD), bicuspid aortic valve (BAV) with thoracic aortic aneurysm or dissection, and subjects under 50 years of age with thoracic aortic aneurysm or dissection (TAAD <50 years). Women comprised 32% of the cohort.

Intervention

Female gender

Comparator

Male gender

Outcome

Gender differences in aortic size, frequency and extent of thoracic aortic dissections, age at operation, total aortic surgeries, and medical therapy (ACEi use)

Among patients with genetically triggered thoracic aortic disease, women undergo fewer aortic surgeries and receive less ACE inhibitor therapy than men, potentially due to their smaller absolute aortic diameters.

Limitations

Cross-sectional design limits ability to determine if women are at higher risk for adverse events
Longitudinal studies are needed

Cite This Study

Holmes et al. (2013) studied this question.

synapsesocial.com/papers/69f6915de405cc4465bc2b2c https://doi.org/10.1002/ajmg.a.35836

Topics

Echocardiography

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Implication

Sex differences in aortic surgery and ACEi use should not change practice; leaves open whether size thresholds disadvantage women with heritable aortopathy.

GenTAC registry report: Gender differences among individuals with genetically triggered thoracic aortic aneurysm and dissection

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

GenTAC registry report: Gender differences among individuals with genetically triggered thoracic aortic aneurysm and dissection

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider