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May 1, 1991Circulation ResearchOpen Access

Vagal stimulation and prevention of sudden death in conscious dogs with a healed myocardial infarction.

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Why the study?

Does vagal stimulation prevent ventricular fibrillation in conscious dogs with a healed myocardial infarction undergoing exercise and acute ischemia?

Population

59 conscious dogs with a healed anterior myocardial infarction that developed ventricular fibrillation…

Comparison

Vagal stimulation via a chronically implantable… vs Control group undergoing the second exercise and…

Design

Preclinical, Assigned to control or vagal device

Authors

EVEmilio VanoliUniversity of PaviaGFGaetano Maria De FerrariCross-Cutting CardiologyMSMarco Stramba‐BadialeElectrophysiology

Discussion

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Implication

Vagal stimulation may protect against VF in post-MI ischemia; leaves open translation to humans and requires clinical trials.

Structured PICO

Does vagal stimulation prevent ventricular fibrillation in conscious dogs with a healed myocardial infarction undergoing exercise and acute ischemia?

P
Population
59 conscious dogs with a healed anterior myocardial infarction (produced 1 month prior) that developed ventricular fibrillation during an initial exercise stress test with 2-minute circumflex coronary artery occlusion.
I
Intervention
Vagal stimulation via a chronically implantable device placed around the cervical right vagus, applied during a second exercise and ischemia test.
C
Comparator
Control group undergoing the second exercise and ischemia test without vagal stimulation.
O
Outcome
Occurrence of ventricular fibrillation during the second exercise and ischemia test.hard clinical

Vagal stimulation effectively prevents ventricular fibrillation during acute ischemia in conscious dogs with a healed myocardial infarction, driven by heart rate reduction and antagonism of sympathetic activity.

Cite This Study

Vanoli et al. (1991) studied this question.

synapsesocial.com/papers/69f69177e405cc4465bc2b90https://doi.org/10.1161/01.res.68.5.1471
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of dorsal root section on the arrhythmias associated with coronary occlusion1976 · 83 citations
  2. 2Effect of Vagal Stimulation and Acetylcholine on the Ventricle1961 · 29 citations
  3. 3Effect of sympathetic tone on ventricular arrhythmias during circumflex coronary occlusion1985 · 42 citations
  4. 4Effect of reflex vagal activation on frequency of ventricular premature complexes1991 · 27 citations
  5. 5Transmembrane Potential Characteristics and Muscarinic and Beta‐Adrenergic Responsiveness in Purkinje Fibers From a Canine Model of Lethal Ventricular Arrhythmias1991 · 2 citations